Mulberry Leaf Extract May Help Manage Type 2 Diabetes

Diabetes


 

Complementary therapies are an appealing option for many patients with chronic disease. A recent study suggests supplementation with mulberry leaf extract may help decrease blood glucose levels after meals in patients with type 2 diabetes.

 

Mulberry leaves have a history of anecdotal use in Asia to treat glucose irregularities and studies in diabetic rats have associated ingestion of mulberry leaf extract with a reduction in blood glucose after feeding. Similar results have been reported in uncontrolled and short-term human studies, but there is a need for more thorough investigations on mulberry leaves as a complementary therapy.

A research team at the University of Mississippi recently carried out a randomized double-blind placebo-controlled pilot study to determine whether mulberry leaf extract can be used as a complementary treatment for type 2 diabetes and published their study in Complimentary Therapies in Medicine. A total of 24 non-insulin dependent type 2 diabetic patients who were on oral therapies were recruited into this three-phase study.

In the first phase, all patients took a placebo 3 times daily and monitored their blood glucose to establish baseline levels for a period of 2 weeks. During the second phase, patients were randomized into either a placebo group oral 1000 mg mulberry leaf extract group. Each group ingested their respective capsules 3 times daily along with meals for a period of 3 months. Follow-ups were carried out at 4 weeks and 3 months into this second phase and involved clinical examinations, questionnaires, self-monitoring of blood glucose (SMBG) evaluations and safety laboratory tests. The final phase of the study consisted of A1C hemoglobin assessment to determine average blood glucose levels over the previous 3 months.

Of the 24 patients who enrolled, a total of 17 completed the study. Patients who ingested mulberry leaf extract were found to have a significant decrease in post-meal SMBG level after 3 months compared to placebo. There was no significant change in pre-meal blood glucose levels. Several patients reported adverse gastrointestinal side effects, but there was no difference in these effects between the two study groups. A1C hemoglobin assessments did not find a significant difference between baseline and 3 month follow-up levels between both groups.

The discrepancy between the SMBG and A1C hemoglobin results may be due to the 3 month time period since the authors suggest at least 6 months treatment may be necessary to see changes in A1C hemoglobin. Other limitations of the study include its small sample size, high patient dropout rate, and a baseline difference in weights between the two study groups which may have affected results.

This is the first placebo-controlled study evaluating mulberry leaf extract used in type 2 diabetes over a longer term 3 month period. Results suggest that mulberry leaf extract can help lower blood glucose levels following meals in non-insulin dependent type 2 diabetics. The authors hope that larger scale, longer term trials will be carried out in the future to explore the potential of mulberry leaf extract as a complementary therapy for type 2 diabetes.

Written by Agustin Dominguez Iino, BSc

Riche DM, Riche KD, East HE, Barrett EK, May WL. Impact of mulberry leaf extract on type 2 diabetes (Mul-DM): A randomized, placebo-controlled pilot study. Complementary Therapies in Medicine. 2017;32:105-108. doi:10.1016/j.ctim.2017.04.006.



Source link

Products You May Like

Articles You May Like

Not Just Humans – Elderly Chimpanzees May Get Alzheimer’s Disease
A Malignant Mesothelioma Treatment Shows No Clinical Benefits
Is Whey Protein Beneficial for Malnutrition in the Elderly?
Improving Traumatic Brain Injury Treatment with Diagnostic Biomarkers
Are Tamoxifen and Exemestane Effective for Reducing Breast Cancer Recurrence?

Leave a Reply

Your email address will not be published. Required fields are marked *