Clinical Trials & Research

Recently published guidelines outline how physicians should deprescribe or taper patient use of proton pump inhibitors, a commonly prescribed class of drugs with problematic long term use.   Proton–pump inhibitors (PPI’s) are a class of drugs recommended for people who suffer from increased acidity in their stomach. The acidity could be the result of a
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Current treatment of osteoarthritis involves nonsteroidal anti-inflammatory drugs (NSAIDs) which are accompanied by numerous adverse effects. Chondroitin sulfate represents a viable alternative that is equally as effective in pain relief and function restoration.   Osteoarthritis (OA) is a disease in which the cartilage providing cushioning between joints wears down. This can result in pain, stiffness,
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The internet is a storehouse of information and, in recent years, patients have taken to searching the internet to decipher symptoms, diseases and possible treatments for illnesses; a phenomenon commonly referred to as “Dr. Google”. Flemish researchers investigated the link between Dr. Google and doctor-patient interactions and found that internet searches did not negatively affect
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Delirium is a costly yet preventable, common post-surgical complication in the elderly population. A recent study shows that an intervention program called mHELP greatly reduces cases of delirium post-surgery in older patients.   Delirium, an acutely disturbed state of mind, is considered the most common complication following surgery in the elderly population. Delirium can have
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In a 2017 study, researchers sought to determine the role of the peroxisome proliferator-activated receptor delta (PPAR-delta) cell signaling pathway in exercise-induced improvements in endurance. The researchers found PPAR-delta improves endurance by reducing glucose release and metabolism and increasing fat metabolism in muscle tissue.   Exercise is believed to improve endurance by reducing the extent
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New opioid drugs with reduced side effects are in development.   Chronic pain is a serious and growing concern. It impacts 1/3 of Americans and severely degrades quality of life. To date, the best treatment to manage chronic pain are opioids such as morphine and fentanyl. Unfortunately, opioids have many side effects, including dependence, addiction,
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Current research shows that rapid detection of Adrenoleukodystrophy can significantly reduce the rate of potential neurological damage in the life span of a male child who is genetically prone to acquiring the disease.   Adrenoleukodystrophy (ALD) is an X-linked genetic disorder that affects the adrenal gland and the nervous system in boys. In its most
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A new article describes research performed on different methods of minimizing pain associated with injectable facial noninvasive cosmetic treatments.   Botulinum toxin, commonly known as Botox (BTX), and soft-tissue filler (STF) have become the two most frequently performed nonsurgical cosmetic facial treatments in the United States, with roughly between 2.1 million and 4.3 million procedures,
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A phenomenon known as antibody-dependent enhancement, whereby previous infection by a different serotype of the same virus increases their infectivity, can seriously increase the vulnerability of individuals to some viral infections. In a recent study published in Science, a group demonstrated that this phenomenon may seriously impact individuals at risk of contracting the Zika virus
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A recently published article compiles an overview of psoriasis diagnosis and treatment for this increasingly prevalent autoimmune inflammatory disease.   Psoriasis is a multisystem inflammatory disease which presents primarily at the skin and joints. It has been estimated to impact 1.7% of Canada’s population. Affecting all sexes equally, the condition is likely to occur between
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There is a new hybrid-molecule against disease-causing, drug resistant bacteria engineered by the researchers at the Rockefeller University.   Unfortunately, the human immune system is poorly equipped to destroy certain disease-causing, drug-resistant bacteria. The problem is that some antibodies do not recognize carbohydrates on bacterial cell walls, meaning the antibodies will not bind to the
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In case you missed it, here are the biggest headlines of the week! Effects of Mediterranean Diet on Endothelial Function and Blood Pressure A group of researchers conducted a randomized control trial to determine whether adherence to Mediterranean diet improved endothelial function and lowered blood pressure levels … [read more]   Is Ketamine with Electroconvulsive
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Multiple sclerosis is a neurologic disease that causes fatigue, loss of sensation, vision impairment, and difficulty with muscle control and coordination. Using a mouse model, researchers found evidence that treatment with nimodipine slowed the rate of nerve cell demyelination and also fostered remyelination.   Multiple sclerosis (MS) is an autoimmune disease which causes damage to
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The Canadian government, under Prime Minister Justin Trudeau, plans on passing new legislation that will legalize recreational marijuana use across Canada for anyone over the age of 18. Despite wide public support, some policy makers and politicians have concerns regarding the logistics and wholesome regulation of recreational marijuana.   Legalizing recreational marijuana has been a
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A consultation paper proposing a risk-based approach to regulation of “self-care” products represents significant change in how cosmetics, natural health products and non-prescription drugs are regulated in Canada.   Health Canada is responsible for regulation of both prescription and non-prescription (or “self-care”) products sold in Canada.  Self-care products cover three categories of goods: Cosmetics, which
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Large scale nuclear disasters, such as in Fukushima and Chernobyl, have raised public concern over nuclear power and radiation exposure through medical procedures. However, most people are unaware that many household items and foods emit potentially dangerous radiation.   Public concern over radiation exposure has been heightened due to nuclear reactor accidents such as those
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A 2016 phase I trial explored the safety, efficacy, and practicality of joint cartilage grafts from nasal chondrocytes in the treatment of knee articular cartilage injuries. For the ten injuries treated, five were repaired completely and three were more than 50% repaired two years post-procedure with only two serious adverse events reported during the trial.
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