Clinical Trials & Research

A recent study published in JAMA Psychiatry found that some adolescents, especially males, who lived in disadvantaged neighbourhoods showed abnormal changes in brain structure from early to late adolescence.   Positive parenting may protect against changes in brain structure, counteracting the biological and functional consequences associated with disadvantage. The biological, psychological, and social consequences of socioeconomic
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A study recently published in the American Journal of Clinical Nutrition explored various factors associated with inflammation in preschool children and women of reproductive age. It was found that recent illness and obesity were consistently associated with inflammation regardless of environment, while commonly measured demographic covariates, such as sex or socioeconomic status, were not.  
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  A new study finds that using soluble transferrin receptor (sTfR) concentrations to estimate nutritional iron deficiency anemia may be inaccurate as sTfR levels are affected in the presence of inflammation and malaria. The study proposes methods to adjust measured sTfR values when inflammation or malaria are present, so that these values reflect nutritional iron
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Uterine leiomyoma are benign soft tissue neoplasms affecting the female reproductive tracts of many women. Mifepristone and enantone are two medical treatment options that are equally safe and effective for treating the symptoms of fibroids.   Uterine leiomyoma, or fibroids, are benign soft tissue tumors first described by Matthew Baille in 1793. They are the
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A recent study examined the effects of gamma-linolenic acid supplementation on kidney stone prevention across white and black race groups. After supplementation for 30 days, the white group showed both increases and decreases in kidney stone risk factors, while the black group remained largely unchanged.   Kidney stones are a common condition caused by the
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  The atypical antipsychotics clozapine and olanzapine are commonly used to treat schizophrenia but unfortunately come with serious side effects including significant weight-gain, metabolic disorders, type II diabetes, and cardiovascular diseases which are responsible for around 60% of excess mortality in schizophrenic patients. An article published in JAMA Psychiatry explains how the glucagon-like peptide-1 (GLP-1)
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A group of researchers in Japan performed a longitudinal study to measure the effects of physical activity on various neurocognitive indicators in people diagnosed with schizophrenia. They found that certain types of exercise are associated with improved executive function and reaction time.   Schizophrenia is a psychological disorder characterized by abnormal thought processes and behaviour,
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Recent research suggests that non-vitamin K antagonist oral anticoagulants (NOACs) are as effective as warfarin for treating atrial fibrillation in high-risk patients.   Atrial fibrillation (AF) is an irregular and rapid heart rate that can increase the risk of stroke, heart failure and other cardiovascular complications. The signs usually include dizziness, fatigue, and weakness. Treatment
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Prolotherapy is a treatment for osteoarthritis that involves injections into or around the articular space to promote regeneration and repair. Scientists researched whether intra-articular injections had negative consequences and how they compared to periartular injections for treating knee osteoarthritis.   Osteoarthritis is a degenerative disease that affects the aging population. It manifests in joints, causing
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The way in which a patient metabolizes folic acid affects the overall prognosis and response to chemotherapy for malignant pleural mesothelioma.   Malignant pleural mesothelioma (MPM) is a rare, aggressive tumor affecting the membranes lining the lungs. Often caused by asbestos exposure, symptoms include shortness of breath, cough, and chest pain due to a build-up
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Malaria is a common parasitic infection that may be linked to various long-term effects, even after the infection has cleared. Lee and colleagues found a direct link between malaria infection and bone loss and problems in bone growth, and suggest vitamin D supplementation as a treatment option.   Malaria is a common, life-threatening infection caused
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A recent New England Journal of Medicine article reports that Rivaroxaban has greater efficacy and  more acceptable side effects than Aspirin in patients with recurrent venous thromboembolisms.   Thrombose, the formation of blood clots, is a medical emergency that requires prompt medical attention. Three factors, commonly referred to as the Virchow triad, contribute to the
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The benefits of sentinel lymph node biopsy in treating skin cancer (melanoma) is well established; however, the value of lymph-node dissection, a procedure in which all nodes located nearby metastasis-positive sentinel nodes are surgically removed, remains controversial. Recently, a phase III clinical trial demonstrated that immediate completion lymph-node dissection is not associated with increased melanoma-specific
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Tuberculosis is a communicable respiratory disease. A group of researchers led by Maeve Lalor conducted a cohort study to determine household transmission of tuberculosis in England by combining epidemiologic and molecular strain typing data.   Tuberculosis is a communicable respiratory disease prevalent in some third world countries. In first world countries where the prevalence of
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Hyaluronic Acid (HA) fillers are the accepted standard for non-surgical correction of nasolabial folds and crow’s feet but clinicians are always looking for the new and improved options. A rigorous evaluation of new HA fillers infused with lidocaine reveals results comparable with currently available formulations.   Hyaluronic acid (HA) is currently the most popular facial
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A new study published in the British Journal of Nutrition reports that alcohol consumption may not be correlated with the occurrence of Barrett’s Esophagus and Erosive Esophagitis.   Barret’s Esophagus (BE) is a condition where the flat lining squamous cells of the food pipe (esophagus) change into a more columnar morphology. Although not immediately cancerous,
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Researchers in Germany have developed “artificial tongues” which can reliably identify different types of whisky. This technique could be used to detect counterfeit whiskies and may have many other applications in the future.   Being able to reliably identify complex substances such as beverages, foodstuffs and prescription drugs is important for both health safety and
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A collaborative team of biomedical engineering researchers have designed a metamaterial which is compact, flexible and easy to integrate into clinical MRI scanners. The metamaterial improves MRI functions, leading to greater sensitivity and images with higher signal-to-noise ratios.   Magnetic Resonance Imaging (MRI) is one of the most common and useful medical imaging modalities used
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A recent study explored the antibacterial effects of modified forms of vancomycin on antibiotic-resistant bacteria. The results suggest C1-aminomethylene vancomycin may be an effective agent against methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic-resistant bacteria.   The ability of bacterial strains to acquire resistance to antibiotics faster than antibacterial therapies can be developed is of growing
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Researchers conducted an observational study to determine the effectiveness of various antipsychotic treatment strategies for schizophrenia. They found that injectable antipsychotics and clozapine were the most effective treatments.   Large scale randomized clinical trials are considered the gold standard in clinical research because they ensure that all variables are accounted for and there are no
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