Clinical Trials & Research

Researchers determine whether oral corticosteroids, such as prednisolone,  reduce symptom duration or severity for acute lower respiratory tract infection in non-asthmatic adults. Acute lower respiratory tract infection (LRTI), defined as an acute cough with at least one of the symptoms of sputum, chest pain, shortness of breath, and wheezing is one of the most common
0 Comments
Behavioural intervention can help decrease psychological distress among women with a history of gender-based violence. A clinical trial determines the effectiveness of a community-taught behavioral treatment on psychological distress. Gender-based violence toward women has been linked to increased mental stress and psychological morbidity in low and middle-income countries worldwide, specifically in urban Kenya. The treatment
0 Comments
Given that the vast majority of opiate-dependent individuals relapse soon after detoxification, a recent study investigated whether the use of medications could assist in reducing the severity of opiate withdrawal. With over 11 million heroin users worldwide, the global health burden of opiate-dependent individuals remains high. Opiates are a class of drugs (including illicit drugs
0 Comments
Despite the availability of chemotherapeutic agents for the treatment of acute lymphoblastic leukemia, some patients won’t respond to the drugs or experience relapse.  A phase 3 clinical trial examined the safety profile of inotuzumabozogazamin, a novel chemotherapeutic drug which has a potential to be used for relapsed and refractory acute lymphoblastic leukemia.   There are
0 Comments
  In a 2017 study, researchers explored the risks and benefits of levothyroxine for subclinical hypothyroidism treatment in older adults. The findings suggest levothyroxine does not improve hypothyroidism symptoms.   Hypothyroidism – underproduction of the thyroid hormone thyroxine and compensatory overproduction of the pituitary hormone which promotes its release, thyroid-stimulating hormone (TSH) –can have profound
0 Comments
Metabolic syndrome and non alcoholic fatty liver disease are conditions that are becoming more prevalent due to an increase of fructose and fats in our diets. A new study examines the role of citrulline in preventing endotoxin-induced injury in a rat model of non alcoholic fatty liver disease and finds that citrulline is able to prevent an inflammatory
0 Comments
Stress urinary incontinence, a condition in which individuals experience incontinence during physical exertion, could affect up to half of older adults and may lead to a reduction in quality of life. In a randomized clinical trial, Liu and colleagues show that electroacupuncture may be an effective treatment for stress urinary incontinence.   Stress urinary incontinence,
0 Comments
The National Audit Office (NAO) published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence, leading to a backlog, by the NHS Shared Business Services (NHS SBS).   The National Audit Office (NAO) in the United Kingdom published a report on July 27th regarding the inappropriate handling of unprocessed clinical correspondence
0 Comments
A recent study published in JAMA Psychiatry found that some adolescents, especially males, who lived in disadvantaged neighbourhoods showed abnormal changes in brain structure from early to late adolescence.   Positive parenting may protect against changes in brain structure, counteracting the biological and functional consequences associated with disadvantage. The biological, psychological, and social consequences of socioeconomic
0 Comments
A study recently published in the American Journal of Clinical Nutrition explored various factors associated with inflammation in preschool children and women of reproductive age. It was found that recent illness and obesity were consistently associated with inflammation regardless of environment, while commonly measured demographic covariates, such as sex or socioeconomic status, were not.  
0 Comments
  A new study finds that using soluble transferrin receptor (sTfR) concentrations to estimate nutritional iron deficiency anemia may be inaccurate as sTfR levels are affected in the presence of inflammation and malaria. The study proposes methods to adjust measured sTfR values when inflammation or malaria are present, so that these values reflect nutritional iron
0 Comments
Uterine leiomyoma are benign soft tissue neoplasms affecting the female reproductive tracts of many women. Mifepristone and enantone are two medical treatment options that are equally safe and effective for treating the symptoms of fibroids.   Uterine leiomyoma, or fibroids, are benign soft tissue tumors first described by Matthew Baille in 1793. They are the
0 Comments
A recent study examined the effects of gamma-linolenic acid supplementation on kidney stone prevention across white and black race groups. After supplementation for 30 days, the white group showed both increases and decreases in kidney stone risk factors, while the black group remained largely unchanged.   Kidney stones are a common condition caused by the
0 Comments
  The atypical antipsychotics clozapine and olanzapine are commonly used to treat schizophrenia but unfortunately come with serious side effects including significant weight-gain, metabolic disorders, type II diabetes, and cardiovascular diseases which are responsible for around 60% of excess mortality in schizophrenic patients. An article published in JAMA Psychiatry explains how the glucagon-like peptide-1 (GLP-1)
0 Comments
A group of researchers in Japan performed a longitudinal study to measure the effects of physical activity on various neurocognitive indicators in people diagnosed with schizophrenia. They found that certain types of exercise are associated with improved executive function and reaction time.   Schizophrenia is a psychological disorder characterized by abnormal thought processes and behaviour,
0 Comments
Recent research suggests that non-vitamin K antagonist oral anticoagulants (NOACs) are as effective as warfarin for treating atrial fibrillation in high-risk patients.   Atrial fibrillation (AF) is an irregular and rapid heart rate that can increase the risk of stroke, heart failure and other cardiovascular complications. The signs usually include dizziness, fatigue, and weakness. Treatment
0 Comments
Prolotherapy is a treatment for osteoarthritis that involves injections into or around the articular space to promote regeneration and repair. Scientists researched whether intra-articular injections had negative consequences and how they compared to periartular injections for treating knee osteoarthritis.   Osteoarthritis is a degenerative disease that affects the aging population. It manifests in joints, causing
0 Comments
The way in which a patient metabolizes folic acid affects the overall prognosis and response to chemotherapy for malignant pleural mesothelioma.   Malignant pleural mesothelioma (MPM) is a rare, aggressive tumor affecting the membranes lining the lungs. Often caused by asbestos exposure, symptoms include shortness of breath, cough, and chest pain due to a build-up
0 Comments