Clinical Trials & Research

A phase-1b trial funded by Merck and Pfizer combined two drugs to evaluate their effectiveness in treating renal cell carcinoma. Renal cell carcinoma makes up 95% of kidney cancer cases. About 338,000 cases of renal cell carcinoma are detected worldwide every year. Renal cell carcinoma is a form of cancer that starts in the small tubules
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A recent study investigated whether pimavanserin, a treatment for Parkinson’s disease psychosis, could also treat Alzheimer’s disease psychosis. Of the approximate 45 million people worldwide suffering from Alzheimer’s disease, between 25-50% of these individuals will at some point also suffer from symptoms of psychosis, the most common being hallucinations and delusions. Psychosis is an impaired relationship
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In a recent study, researchers examined the effects of amobarbital and N-acetylcysteine on post-traumatic osteoarthritis in injured joints. Injury to load-bearing joints such as the knees or ankles can result in posttraumatic osteoarthritis (PTOA), a condition in which the shock-absorbing and friction-reducing joint cartilage breaks down over time. Evidence suggests that metabolic changes in cartilage-producing
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Researchers attempt to identify a therapeutic target that encourages respiratory muscle relaxation to provide asthma relief. Asthma causes respiratory problems, which can manifest as wheezing and chest tightness. It is a common affliction that affects about 10% of the US population. There has been much research focused on discovering therapeutic targets for asthma relief, such
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A recent article in The Lancet showcases encouraging results from two Zika virus gene-based vaccine candidates being developed in the USA. The Zika virus is a growing global health concern. Outbreaks of the Zika virus occurred in 2006, 2013, and 2015 on different continents across the world. There is currently no vaccine available for the
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Researchers in the US determine whether an antibody drug, solanezumab, can slow cognitive decline in patients with mild dementia. Alzheimer’s disease is thought to arise from a buildup of amyloid-beta (Aβ) plaques and neurofibrillary tangles in the brain. Those with Alzheimer’s disease may also show signs of mild dementia. The Aβ hypothesis suggests that Aβ
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Recent phase 3 clinical trials compared the efficacy and safety of a novel two-drug regimen, with the standard three-drug antiretroviral therapy for HIV. Antiretroviral therapy (ART), comprised of two nucleoside reverse transcriptase inhibitors (NRTIs) and a third drug, is the first- and second-line treatment for patients with an HIV infection. The use of NRTIs is
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An episodic migraine is a debilitating headache disorder with few effective and safe preventative treatments available. Researchers in this study conducted a trial on erenumab, to determine its effectiveness in providing relief for people suffering from episodic migraines. Migraines are defined as a debilitating headache disorder that manifests as a throbbing headache which can last
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Researchers at Spark Therapeutics and Pfizer tested the safety and efficacy of a new hemophilia gene therapy vector for the treatment of hemophilia B. The body’s ability to stop bleeding and repair damaged blood vessels depends heavily upon a variety of clot-forming enzymes. Deficiency in one such enzyme, coagulation factor IX, results in the development
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Scientists are investigating the effectiveness of using galcanezumab to prevent migraines, a monoclonal antibody that targets the proteins involved in migraine pathophysiology. Migraines are chronic, debilitating headaches that can last a few hours or up to a few days. The cost to migraine sufferers is quite high when considering absenteeism from school or work and
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In a recent multinational clinical trial, researchers evaluated the effectiveness of two fremanezumab regimens for chronic migraine prevention. The transmission of pain signals during migraines is thought to be carried out in part by the release of calcitonin gene-related peptide (CGRP) from one nerve and reception by the next. Early trials have shown that fremanezumab,
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A recent study evaluated the effectiveness of using a subcutaneous injection to prevent postherpetic neuralgia, a common complication of shingles. Chickenpox is a common childhood infection caused by the herpes zoster virus. However, once the rash caused by the virus has cleared up, the virus can lay dormant for years. Later in life, or due
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A clinical trial involving patients with heart diseases has revealed new dimensions of the role of anti-inflammatory medications in preventing heart attacks. Like many diseases, it’s been proven that inflammation can be an underlying predisposing factor for cardiovascular diseases including heart attacks and strokes. Investigations about the role of inflammatory pathways in developing cardiovascular disease
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Researchers test the safety and efficacy of a natural anti-fungal treatment derived from spirulina to treat severe fungal infections of the skin and nails. Superficial fungal infections of the hair, skin, or nails, also referred to dermatophytosis, affects about a quarter of the world’s population. Topical anti-fungal treatment creams can be used to treat dermatophytosis,
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The NIH has amended its definition of clinical trials to include brain studies, introducing new regulations considered unnecessary by many researchers. The National Institutes of Health (NIH) has implemented its controversial decision to broaden the scope of clinical trials to include cognitive and behavioural studies. This change, which has been in discussion since at least
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Researchers determine whether oral corticosteroids, such as prednisolone,  reduce symptom duration or severity for acute lower respiratory tract infection in non-asthmatic adults. Acute lower respiratory tract infection (LRTI), defined as an acute cough with at least one of the symptoms of sputum, chest pain, shortness of breath, and wheezing is one of the most common
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Behavioural intervention can help decrease psychological distress among women with a history of gender-based violence. A clinical trial determines the effectiveness of a community-taught behavioral treatment on psychological distress. Gender-based violence toward women has been linked to increased mental stress and psychological morbidity in low and middle-income countries worldwide, specifically in urban Kenya. The treatment
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Given that the vast majority of opiate-dependent individuals relapse soon after detoxification, a recent study investigated whether the use of medications could assist in reducing the severity of opiate withdrawal. With over 11 million heroin users worldwide, the global health burden of opiate-dependent individuals remains high. Opiates are a class of drugs (including illicit drugs
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Despite the availability of chemotherapeutic agents for the treatment of acute lymphoblastic leukemia, some patients won’t respond to the drugs or experience relapse.  A phase 3 clinical trial examined the safety profile of inotuzumabozogazamin, a novel chemotherapeutic drug which has a potential to be used for relapsed and refractory acute lymphoblastic leukemia.   There are
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  In a 2017 study, researchers explored the risks and benefits of levothyroxine for subclinical hypothyroidism treatment in older adults. The findings suggest levothyroxine does not improve hypothyroidism symptoms.   Hypothyroidism – underproduction of the thyroid hormone thyroxine and compensatory overproduction of the pituitary hormone which promotes its release, thyroid-stimulating hormone (TSH) –can have profound
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Metabolic syndrome and non alcoholic fatty liver disease are conditions that are becoming more prevalent due to an increase of fructose and fats in our diets. A new study examines the role of citrulline in preventing endotoxin-induced injury in a rat model of non alcoholic fatty liver disease and finds that citrulline is able to prevent an inflammatory
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Stress urinary incontinence, a condition in which individuals experience incontinence during physical exertion, could affect up to half of older adults and may lead to a reduction in quality of life. In a randomized clinical trial, Liu and colleagues show that electroacupuncture may be an effective treatment for stress urinary incontinence.   Stress urinary incontinence,
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