Aging

The endopeptidase delta-secretase is partly responsible for mediating the accumulation of beta-amyloid plaques and tau protein aggregates: two prime suspects in the pathogenesis of Alzheimer’s disease. A new study reports an orally bioactive and highly selective small molecule inhibitor of delta-secretase that can prevent the accumulation of aggregated proteins and improve cognition in mouse models
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There is a demographic gap between babies born with HIV in the past and recently. Older patients are at an increased risk for viral load in blood, immunosuppression, more severe clinical events, and mortality compared to those born recently due to advances in treatments starting at an earlier age.   Current antiretroviral (ARV) and combination
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Episodes of dementia symptomatic of Alzheimer’s disease (AD) often require treatment with anxiolytics such as benzodiazepines (BZ). This treatment has previously been suggested to be associated with pneumonia as an unexpected side effect, although the evidence is contradictory. In a recent retrospective study, a group of Finland practitioners provide evidence supporting that suggests BZ treatment
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Frailty is a risk factor that particularly affects the elderly population, which is predominantly female. Nutrition has been identified as a key contributor to frailty, and with diet modification, a potential therapeutic target.   With advances in science and medicine, our population is living to ages that we have not seen before. This comes with
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An ex vivo and a clinical trial were conducted by researchers from France to determine the efficacy of glucosamine sulphate in preventing skin aging.   Glucosamine sulphate is a naturally occurring compound in the body, aiding in the production of different substances such as hyaluronic acid, heparan sulfate, and glycosaminoglycans. Glycosaminoglycans, together with elastin and collagen,
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Researchers in India report that yoga postures, breathing disciplines and meditation may be the key to prolonging that proverbial fountain of youth. Biomarkers found in human blood samples drawn during a clinical trial showed the anti-aging benefits of practicing these ancient holistic practices.   In the Yoga and Meditation Based Lifestyle Intervention (YMLI) clinical trial,
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